Obesity

Why trials studying Obesity stopped, in this sample of ClinicalTrials.gov.

82 stopped trials with a clear reason; 91% ended for non-scientific reasons.

Trials

• A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight
  NCT07357766 · WITHDRAWN · funding business
  “The study is withdrawn due to strategic reasons.”
• A Study of Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
  NCT07553299 · TERMINATED · funding business
  “The Study Sponsor made a business decision not to continue the study. The decision was not based on safety findings.”
• A Phase 3, Double-blind/Double-dummy, Safety/Efficacy/Superiority of Sibutramine/Topiramate XR in Adults With Overweight
  NCT05209984 · WITHDRAWN · funding business
  “Strategic change in development priorities”
• Early Childhood Obesity Among Rural Residents of West Texas
  NCT06831097 · WITHDRAWN · slow accrual
  “Enrollment issues”
• A Study of Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Participants With Obesity or Overweight With Type 2 Diabetes
  NCT06901349 · WITHDRAWN · funding business
  “Study terminated for strategic business reasons”
• Study to Learn About How the Study Medicines Called PF-07976016 and PF-06882961 Are Taken Up by the Body, and if Either of Them Change How the Body Processes the Other Medicine in Otherwise Healthy Adults With Overweight or Obesity
  NCT06910839 · TERMINATED · funding business
  “The sponsor has made the decision to discontinue development of danuglipron (PF-06882961). As such, this study was discontinued prior to PF-06882961 administration.”
• Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared with Tirzepatide Alone in Participants with Obesity Aged 55 Years and Over
  NCT06515418 · TERMINATED · other
  “Dosing of both study drugs has been discontinued due to observation of liver transaminitis without clinically significant symptoms in some subjects receiving azelaprag. All participant visits have been completed.”
• A Phase 1b Study to Evaluate the Safety of XEN-101
  NCT06417697 · TERMINATED · futility
  “Study not stopped for safety reasons. Data were reviewed after the first 23 patients had completed scheduled dosing and there was no signal of efficacy for change in body weight. This clinical trial has been determined to be futile.”
• Identifying Strategies to Curtail Weight Regain After GLP-1 Receptor Agonist Treatment Cessation
  NCT06273163 · TERMINATED · slow accrual
  “Funding ended, unable to reach recruitment goal.”
• Ultrasonic Treatment of Food Addiction
  NCT06249711 · WITHDRAWN · logistics pi
  “Not activated at the site level”
• Evaluation of Exercise Application Technology in Adolescents
  NCT05720377 · WITHDRAWN · funding business
  “Funding not obtained”
• Behavioral Plant-Based Dietary Intervention in Latinos
  NCT05444595 · WITHDRAWN · logistics pi
  “Administrative reasons”
• A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and Effect of GLP-1 Drug Semaglutide on Midazolam Blood Levels in Healthy Adults With Weight in the Obesity Range
  NCT05671653 · TERMINATED · funding business
  “The decision to terminate clinical development of lotiglipron is based on pharmacokinetic data from Phase 1 drug-drug-interaction studies and laboratory measurements of elevated transaminases in these Phase 1 studies as well as a Phase 2 study.”
• Health After Birth Intervention Trial
  NCT05137691 · TERMINATED · slow accrual
  “Recruitment challenges”
• Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity
  NCT05530434 · TERMINATED · slow accrual
  “Slow enrollment”
• Deep Brain Stimulation Effects in Patients With Chronic Refractory Obesity
  NCT04453020 · WITHDRAWN · slow accrual
  “The advent of GLP-1 medications for obesity has hampered successful recruitment. No subjects were consented nor enrolled into this study since the start date.”
• Impact of Wearing a Support Garment Following Parietal Gastrectomy
  NCT04938310 · TERMINATED · funding business
  “Study stopped prematurely by sponsor due to lack of funding following company closure”
• The Effect of Traxi Panniculus Retractor on Surgical Time at Non-emergent Cesarean Delivery in Obese Women
  NCT04458415 · WITHDRAWN · funding business
  “Collaborator discontinued at this site to pursue the study with a different site.”
• A Banded One Anastomosis Gastric Bypass With Use Shape-memory Ring Versus Non-banded One Anastomosis Gastric Bypass
  NCT04762849 · WITHDRAWN · slow accrual
  “No Participants Enrolled”
• Perioperative Systemic Lidocaine for Enhanced Bowel Recovery After Bariatric Surgery
  NCT02607488 · SUSPENDED · funding business
  “No fund no enough recruiting centers”
• Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial Fat
  NCT02920190 · WITHDRAWN · funding business
  “Lack of funds to cover the costs of the study medications”
• EASiVENT Study Comparing INTELLiVENT-ASV vs Non Automated Ventilation in Adult ICU Patients
  NCT04400643 · TERMINATED · funding business
  “Sponsor decided to terminate the study, to terminate enrollment at this time is solely due to business reasons. No safety concerns related to the device have been identified which have in any way impacted the decision to stop the study.”
• Effects of a Three-Month Low Calorie Diet Weight Loss Intervention on Knee Replacement Outcomes
  NCT04015011 · TERMINATED · slow accrual
  “study enrollment ended early due to covid and lack of continued funding”
• Vitamin D and Type 2 Diabetes Risk in UK Adults
  NCT04339530 · SUSPENDED · logistics pi
  “This study is suspended until further notice. Recruitment should resume when COVID-19 safety restrictions are lifted.”
• Telenutrition Center: Examining the Implementation of Behavioral Therapy for Obesity
  NCT03855566 · TERMINATED · logistics pi
  “The study was disrupted by and results confounded by the COVID-19 pandemic and there it was not possible to meet study goals within the required timeframe.”
• Church, Extension and Academic Partners Empowering Healthy Families
  NCT03980262 · TERMINATED · slow accrual
  “Faith-based partners were not able to recruit sufficient number of families with young children; funding agency approved shift to qualitative study to identify challenges and potential solutions for future faith-partnered health intervention studies.”
• Glucose Uptake in Metabolic Tissues After Bariatric Surgery
  NCT03563885 · TERMINATED · funding business
  “Financial and Method issues suggesting that study is not feasible.”
• Intranasal Oxytocin and Food Intake in Obese Adolescents
  NCT03497988 · WITHDRAWN · funding business
  “Grant proposal not funded, study has been withdrawn with IRB”
• Effects of Sugary Drink Warning Labels
  NCT03654586 · TERMINATED · logistics pi
  “Study halted prematurely during COVID-19 outbreak”
• Examination of Cognitive Function in Obesity and Following Weight Loss
  NCT02994186 · WITHDRAWN · funding business
  “funding”
• Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction
  NCT01422733 · WITHDRAWN · funding business
  “The study team decided not to pursue this study.”
• Weight Loss Using a Feedback Device in Obese People With the Metabolic Syndrome
  NCT03491930 · WITHDRAWN · logistics pi
  “Study never initiated. PI withdrew protocol with the IRB.”
• Effect of Short Term Adrenal Suppression on Androgen Overproduction in Overweight Girls With Androgen Excess
  NCT01422707 · WITHDRAWN · funding business
  “The study team decided not to pursue this study.”
• Cardiometabolic Disease and Pulmonary Hypertension
  NCT03349775 · TERMINATED · safety
  “After discussion with the Data Safety Monitoring Board and NIH, the randomized clinical trial involving metformin vs. placebo is terminated due to slow enrollment in the setting of the COVID-19 pandemic.”
• School Lunch Salad Bars and Fruit and Vegetable Consumption
  NCT03283033 · TERMINATED · logistics pi
  “COVID-19 closed schools in March 2020. Data collection for all elementary schools was completed pre-pandemic. For middle and high schools, the marketing phase was halted. Results will solely reflect the salad bar intervention.”
• Effects of Exercise Mode on Cardiac Fat and Function
  NCT03297333 · TERMINATED · logistics pi
  “Covid/19”
• Exercise in Targeting Metabolic Dysregulation in Stage I-III Breast or Prostate Cancer Survivors
  NCT03284346 · TERMINATED · logistics pi
  “PI left”
• Naltrexone-Bupropion Versus Placebo-Bupropion for Weight Loss in Schizophrenia
  NCT03132571 · TERMINATED · funding business
  “Study discontinued due to funding.”
• Pilot Intervention-Exercise for the Weight, Healthy Eating, and Exercise for the Long-Haul
  NCT03147209 · WITHDRAWN · funding business
  “Never received funding.”
• Dermatome Electrical Stimulation on Individuals With Overweight and Class I Obesity
  NCT03261531 · TERMINATED · manufacturing supply
  “Device failure”
• Study of Amino Acid Supplementation for Patients With an Excessive Loss of Muscular Body Mass After Obesity Surgery.
  NCT02716740 · TERMINATED · slow accrual
  “not enough patient”
• Transcriptomics of Mononuclear Cells and Inflammatory Status of Obese Patients Treated With Omega-3 Fatty Acids
  NCT05219890 · WITHDRAWN · slow accrual
  “We reached the number of participants required.”
• The Significance of Vitamin D Storage in Adipose Tissue
  NCT01728987 · WITHDRAWN · funding business
  “study stopped due to Financial problems”
• TOP-mums, for a Healthy Start
  NCT02703753 · TERMINATED · logistics pi
  “Inclusion was too slow, a lot of data loss during COVID pandemic”
• Surgical vs. Lifestyle in Obese Older Adults
  NCT03137329 · TERMINATED · slow accrual
  “Did not meet enrollment requirements with limited funding”
• Upgrade the Grains Study: Increasing Whole Grain Consumption in Low-income Children With Obesity
  NCT02719730 · TERMINATED · other
  “Change in study design to be a pilot with no randomization to intervention/control”
• Addressing Post Cessation Weight Gain
  NCT02412631 · TERMINATED · manufacturing supply
  “Lorcaserin removed from market”
• Preoperative Treatment With Noninvasive Intra-auricular Vagus Nerve Stimulation Pending Bariatric Surgery
  NCT02648191 · TERMINATED · slow accrual
  “Lack of inclusion and departure of the investigator”
• RELIEF Europe Study
  NCT02762487 · TERMINATED · slow accrual
  “Insufficient enrollment”
• The Long Term Effect of Adjustable Spaatz 3 Intragastric Balloon on Weight Loss
  NCT02003872 · TERMINATED · slow accrual
  “Stopeed due to lack of recruitment”
• An Efficacy and Safety Study of Beloranib in Obese Subjects With Type 2 Diabetes Mellitus
  NCT02324491 · TERMINATED · funding business
  “Sponsor decision to analyze available safety and efficacy data”
• PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes
  NCT02282423 · TERMINATED · logistics pi
  “PI job change”
• A Role for Brown Adipose Tissue in Postprandial Thermogenesis?
  NCT01974778 · TERMINATED · slow accrual
  “Participant numbers too low. Could not ingest required fat.”
• Healthy Body Study
  NCT02011646 · TERMINATED · logistics pi
  “The PI changed institutions”
• Sulphate-bicarbonate-calcium Water, Body Weight and Gut Microbiota
  NCT02154230 · WITHDRAWN · slow accrual
  “failure to enroll”
• Insulin Resistance Before and During Pregnancy in Women With Polycystic Ovary Syndrome
  NCT01475565 · TERMINATED · slow accrual
  “Only 2 participants were enrolled”
• Pedometer Use to Prevent Excessive Pregnancy Weight Gain in Overweight Women
  NCT01469260 · TERMINATED · logistics pi
  “resources”
• Impact of Laparoscopic Gastric Bypass Surgery and Weight Reduction on Lower Esophageal Sphincter (LES)
  NCT01672034 · WITHDRAWN · slow accrual
  “no patient enrolled”
• Healthy Eating for Reproductive Health: Greenville
  NCT01716429 · WITHDRAWN · slow accrual
  “No participants were recruited over the course of the study time period”
• Vikings Fitness Playbook: A Family Based Lifestyle Modification Program for Overweight and Obese Youth
  NCT01442415 · TERMINATED · slow accrual
  “Unable to achieve enrollment goal.”
• Think AHEAD (A Healthy Eating And Drinking) Study
  NCT01044134 · TERMINATED · slow accrual
  “We achieved n=38, due to slow recruitment (=2/3 of target).”
• The Effect of Weight Loss on Psoriasis Area Severity Index in Adult Psoriasis Patients
  NCT01137448 · WITHDRAWN · slow accrual
  “The site did not have enough funds to complete study arrengments and start to enrolling. The site was not able to enroll subjects.”
• Pediatric Obesity Research Registry
  NCT01046201 · WITHDRAWN · slow accrual
  “To revise protocol for a more concise inclusion/exclusion criteria”
• Investigation of Neuro-hormonal Mechanisms of Hunger, Fullness and Obesity.
  NCT01008371 · WITHDRAWN · slow accrual
  “No recruitment”
• Ghrelin Regulation and Structure: Effect of Thiazolidinedione Therapy on Ghrelin
  NCT00843791 · TERMINATED · funding business
  “Insufficient funds to continue.”
• Pioglitazone Therapy in Obese Children With Insulin Resistance: A Randomized, Controlled Pilot Study
  NCT00775164 · WITHDRAWN · slow accrual
  “Inadequate enrollment”
• Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics (Glitz Asthma)
  NCT00787644 · TERMINATED · safety
  “new safety concerns which emerged about pioglitazone during the trial”
• Anesthesic Propofol and Remifentanil Requirements in Obese Patients
  NCT00779844 · TERMINATED · slow accrual
  “difficulty in recruiting”
• Chromium Piccolinate in the Prevention of Weight Gain Induced by Serotonergic Medications Initiated on Psychiatric Inpatient Units.
  NCT00759993 · TERMINATED · slow accrual
  “inability to recruit and retain”
• A Study to Determine the Effects of TM30339 on Weight Loss in Obese Individuals.
  NCT00746824 · TERMINATED · regulatory
  “The IND was withdrawn.”
• Metformin for Weight Loss in Schizophrenia
  NCT01177709 · TERMINATED · logistics pi
  “PI moved to different institution. Decided to concentrate on different studies.”
• Long-Term Follow-up of Ohio State University Medical Center (OSUMC) Bariatric Patients
  NCT00700843 · TERMINATED · slow accrual
  “Difficulty recruiting”
• The Effect of Rimonabant on Energy Expenditure, Fat Metabolism and Body Composition
  NCT00584389 · TERMINATED · regulatory
  “Suspension of licence for rimonabant by European Medicines Agency”
• Genomic Search for Childhood Obesity Genes-A Pilot Study
  NCT00484172 · WITHDRAWN · logistics pi
  “Study Withdrawn due to Investigator leaving”
• Effects of TNF-alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and Psoriasis
  NCT00477191 · TERMINATED · slow accrual
  “Difficulty in recruitment.”
• Effect of Glycemic Load on Body Composition
  NCT00603655 · TERMINATED · other
  “Higher drop out than expected. Lower Statistical Power.”
• Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass
  NCT00394212 · TERMINATED · funding business
  “For business reasons”
• Effects of Obesity on Care and Outcomes in Mechanically Ventilated Individuals in the Intensive Care Unit
  NCT00296088 · TERMINATED · logistics pi
  “PI left institution”
• Obesity and Weight Loss on Reproductive Function
  NCT00143078 · TERMINATED · funding business
  “Close-out of the grant - study ceased on 1/1/2010”
• Genomic Dissection of a QTL Affecting the Lipid Profile
  NCT00064688 · WITHDRAWN · funding business
  “This protocol was created to support work as part of an NIH-funded study.”
• Topiramate: Long-Term Maintenance of Weight Loss Induced by Low-Calorie Diet in Obese Subjects
  NCT02040311 · TERMINATED · funding business
  “Study was terminated early as sponsor wanted to develop an improved formulation.”
• Magnetic Resonance Imaging-Portfolio Diet Study #7
  NCT02078635 · WITHDRAWN · other
  “Study was amalgamated with another study to include exercise as another intervention.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.