Neoplasms

Why trials studying Neoplasms stopped, in this sample of ClinicalTrials.gov.

24 stopped trials with a clear reason; 83% ended for non-scientific reasons.

Trials

• (HARMONY) Study of BLU-701 in EGFR-mutant NSCLC
  NCT05153408 · TERMINATED · futility
  “Lack of efficacy”
• Mirtazapine in Cancer-related Poly-symptomatology
  NCT04763135 · TERMINATED · slow accrual
  “difficulties in recruiting”
• A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)
  NCT04222972 · TERMINATED · funding business
  “Early termination of the study resulted from organizational and commercial decisions that led to the discontinuation of pralsetinib's global marketing and development in all territories (excluding US and Greater China).”
• Natural Killer Cell (CYNK-001) Infusions in Adults with AML
  NCT04310592 · TERMINATED · funding business
  “Business reasons”
• A Study of CC-95251, a Monoclonal Antibody Directed Against SIRPα, in Participants With Advanced Solid and Hematologic Cancers
  NCT03783403 · TERMINATED · funding business
  “Business objectives have changed.”
• First Time in Humans (FTIH) Study of GSK3368715 in Participants With Solid Tumors and Diffuse Large B-cell Lymphoma (DLBCL)
  NCT03666988 · TERMINATED · futility
  “Overall benefit-risk profile did not support continuation of the study”
• A Trial For Participants With Ewing's Sarcoma Treated With Vigil in Combination With Irinotecan and Temozolomide
  NCT03495921 · TERMINATED · funding business
  “Slow accrual and as a result, a strategic business decision was made to terminate enrollment.”
• A Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of CC-90010 in Subjects With Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin's Lymphomas
  NCT03220347 · TERMINATED · funding business
  “Business objectives have changed”
• Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancer
  NCT02732327 · TERMINATED · funding business
  “No longer aligned with the revised clinical development plan and commercial strategy”
• Impact of Availability of Showerpatch for Patients With Intravenous Catheters
  NCT02324868 · TERMINATED · logistics pi
  “logistic problems”
• National Swiss Sarcoma Cohort Study
  NCT02775799 · TERMINATED · logistics pi
  “Principal Investigator has left the Institution”
• Ganetespib and Ziv-Aflibercept in Refractory Gastrointestinal Carcinomas, Non-Squamous Non-Small Cell Lung Carcinomas, Urothelial Carcinomas, and Sarcomas
  NCT02192541 · TERMINATED · funding business
  “Drug supplier suspended further clinical development of Ganetespib”
• A Psychosocial Intervention Plus Early Palliative Care in the Reduction of Depression of Advanced Cancer Patients
  NCT02133274 · TERMINATED · futility
  “Planned interim analysis did not show the expected benefit of intervention A over B (effect size \<0.2).”
• Continuous Lenalidomide Therapy Versus Observation Following Induction Without Lenalidomide, Pomalidomide or Thalidomide in Myeloma
  NCT02155634 · WITHDRAWN · slow accrual
  “The study was terminated due to poor feasibility and lack of interest at the participating sites.”
• Dose-escalation, Safety and Pharmacokinetic Study of Briciclib in Advanced Solid Tumors
  NCT02168725 · TERMINATED · funding business
  “The study was placed on hold by the FDA due to manufacturing issues and was not restarted.”
• Stress, Exercise Behavior and Survival in Patients With Newly Diagnosed Glioblastoma and in a Close Partner
  NCT02129335 · TERMINATED · slow accrual
  “insufficient enrollment”
• Per-operating Use of a Probe for Detection of β+
  NCT02666599 · TERMINATED · slow accrual
  “lack of recruitment”
• A Phase I Study of OSI-906 in Combination With Pemetrexed in Advanced Solid Tumor Malignancies
  NCT01567384 · WITHDRAWN · funding business
  “The sponsor withdrew support for the study before any patients were enrolled.”
• Response to Influenza Vaccine in Patients With Non-Hematologic Malignancies Receiving Chemotherapy
  NCT01695733 · TERMINATED · funding business
  “no longer had funding to continue”
• Intended Use Study of the BD SurePath Plus™ Pap
  NCT01234480 · TERMINATED · funding business
  “Decided not to pursue commercialization of the product”
• Therapy Study of Automated Protocolized vs. Physician-Directed Non-Protocolized Weaning
  NCT00606788 · SUSPENDED · other
  “Interim analysis indicated that sample size of study patients had to be highly increased to obtain significant outcomes.”
• A Study to Assess the Response Rate of PROCRIT (Epoetin Alfa) Given at a Dose of 40,000 Units Once a Week to Cancer Patients With Anemia Who Are Not Receiving Chemotherapy.
  NCT00350090 · TERMINATED · slow accrual
  “This study was stopped early due to slow enrollment.”
• Hyperthermia Treatment in Conjunction With Mitomycin C Versus Bacillus Calmette-Guérin Immunotherapy (BCG) for Superficial Bladder Cancer
  NCT00384891 · TERMINATED · slow accrual
  “slow accrual”
• SHTC - EUROPE-1 Synergo Hyperthermia-Chemotherapy by European Urologists' Research Operation Preserving Evolution Study I
  NCT02254915 · WITHDRAWN · manufacturing supply
  “Shortages of the active comparator drug (BCG) on the market worldwide and a growing uncertainty as to its future supply.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.