Hypertension

Why trials studying Hypertension stopped, in this sample of ClinicalTrials.gov.

45 stopped trials with a clear reason; 96% ended for non-scientific reasons.

Trials

• Continual vs. Routine Home Blood Pressure Monitoring and Management in Diverse Community Practice: CHANGE-BP
  NCT05746117 · WITHDRAWN · funding business
  “Study aborted by the sponsor”
• Evaluation of the Effectiveness of an Intervention to Reduce Gaps in Hypertension Care in Low-income Medellin, Colombia
  NCT05011838 · WITHDRAWN · logistics pi
  “Due to the devasting impact of Covid-19 on Colombian health services, the execution of the study was halted shortly after all involved actors had been trained”
• Fluid Overload Management and Vascular Stiffness in Chronic Kidney Disease Patients With Hypertension
  NCT05378750 · TERMINATED · slow accrual
  “Recruitment difficulties”
• Utilizing Telemedicine for Hypertension Treatment Lifestyle Modification in Central Harlem
  NCT05062473 · WITHDRAWN · slow accrual
  “Low accrual”
• Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
  NCT04591808 · TERMINATED · funding business
  “for strategic reasons”
• ANGIOTENSIN AGENTS AND REDUCTION OF THE PRESCRIPTION OF ANTIDEPRESSANT DRUGS: A RETROSPECTIVE COHORT STUDY USING REAL-WORLD DATA
  NCT04899206 · WITHDRAWN · funding business
  “Lack of funding”
• The Effect of Timing of Antihypertensive Medication on Diurnal Fluctuations in Blood Pressure Using a Wearable Sensor With Continuous Monitoring
  NCT04826250 · WITHDRAWN · funding business
  “Preliminary data was not sufficient to support the study aim”
• Urica Cor Intervention (URICORI) Trial
  NCT04459936 · WITHDRAWN · logistics pi
  “The study has been terminated due to inclusion difficulties during the worldwide Covid-19 pandemic.”
• Coronavirus (COVID-19) ACEi/ARB Investigation
  NCT04330300 · SUSPENDED · logistics pi
  “Challenges with funding and very low incidence of COVID-19 at Irish study site”
• Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) Cognitive Sub-Study
  NCT03785067 · TERMINATED · funding business
  “Contractual and financial issues.”
• Community Models for Hypertension and Diabetes Care for Refugees
  NCT04229667 · TERMINATED · logistics pi
  “As a result of COVID-19, the intervention design changed and an RCT was no longer an appropriate study design for evaluation.”
• A Research Study to Show Aprocitentan is Efficacious and Safe to Treat Patients With Uncontrolled Blood Pressure and Chronic Kidney Disease.
  NCT04162366 · WITHDRAWN · funding business
  “A business decision was made to not initiate this study”
• Integrated NCD Intervention in Rural Nepal
  NCT04087369 · WITHDRAWN · funding business
  “This study was withdrawn prior to participant enrollment due to a lack of external funding, dedicated resources, and shifting organizational priorities among research collaborators”
• South Asian Low-sodium Trial
  NCT05136911 · TERMINATED · logistics pi
  “The recruitment was stopped due to province-wide lockdown secondary to COVID-19. Blood pressure screenings were conducted in community centres and due to province wide lockdown, further screenings could not be continued.”
• Approaches to Reduce Clinical Inertia in Hypertension in the Dominican Republic
  NCT03954951 · WITHDRAWN · slow accrual
  “Unable to recruit/maintain participants for intervention”
• Enhancing Systems of Care to Improve Hypertension Guideline Implementation
  NCT03563872 · WITHDRAWN · funding business
  “Lack of funding”
• Using Lay Health Advisors to Improve Hypertension Management
  NCT03515005 · TERMINATED · slow accrual
  “Enrollment target not reached”
• Clinical Characteristics of Parkinson's Disease Subjects With Severe Hypertension During Motor OFFs.
  NCT03433950 · SUSPENDED · logistics pi
  “COVID-19 Research Restrictions”
• Peru Longitudinal Study
  NCT03742219 · TERMINATED · slow accrual
  “Low level of returning participants year by year.”
• A Multicenter Study to Evaluate the ROX Coupler in Subjects With Hypertension
  NCT02895386 · TERMINATED · funding business
  “Company/Sponsor has discontinued business”
• Feasibility of Home Telehealth Monitoring for Improvement in Management of Hypertension for Secondary Stroke Prevention
  NCT03517709 · WITHDRAWN · slow accrual
  “No recruitment of subjects”
• Telemonitoring of Uncontrolled Hypertension
  NCT02730052 · WITHDRAWN · slow accrual
  “Centers recruited poorly”
• The Long Term Effect of Adjustable Spaatz 3 Intragastric Balloon on Weight Loss
  NCT02003872 · TERMINATED · slow accrual
  “Stopeed due to lack of recruitment”
• Assessing Alternative Approaches for Blood Pressure Control: A3BC Trial
  NCT02110381 · TERMINATED · slow accrual
  “It was a pilot study and we enrolled sufficient numbers to evaluate the proposed outcomes.”
• Is a Smartphone Application Effective as an Oral Medication Adherence Aid
  NCT01968876 · TERMINATED · regulatory
  “Study had a minor contingency that could not be resolved with the IRB.”
• EnligHTN IV Trial - Multicenter Sham-controlled RCT of Renal Denervation for Hypertension
  NCT01903187 · TERMINATED · regulatory
  “There were no safety or effectiveness concerns. There were concerns about completing enrollment due to a competitive device's potential approval.”
• IntErnational Long-term Follow-up Study of Patients With Uncontrolled HyperTensioN
  NCT01705080 · TERMINATED · funding business
  “Abbott made a decision to not further develop the RDN program.”
• Renal Denervation Hypertension After Stroke
  NCT01689415 · TERMINATED · funding business
  “Based on results from SYMPLICITY HTN-3”
• ACEI/ARB Study in Ambulatory and Day of Surgery Admission Patients
  NCT03121092 · TERMINATED · slow accrual
  “Due to difficulty with recruiting patients meeting the inclusion criteria the PI decided to retire this project.”
• The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients
  NCT01526876 · WITHDRAWN · funding business
  “Terminated by Sponsor”
• Clinical Pharmacology of Aliskiren in Combination With Cyclosporine in Cardiac Transplantation
  NCT01235910 · TERMINATED · slow accrual
  “Study was stopped early due to difficulty finding patients who met I/E criteria.”
• Effect of Eplerenone in Elderly Hypertensive Early Stage Chronic Kidney Disease (CKD) Patients
  NCT01302236 · WITHDRAWN · slow accrual
  “We could not find patients who agreed to enrolled this clinical study.”
• Antihypertensive Efficacy of Fixed Combination Drug
  NCT01211314 · TERMINATED · funding business
  “sponsor decision”
• Combined Renin Inhibition/Beta-blockade
  NCT00627861 · TERMINATED · manufacturing supply
  “The renin laboratory used in the study is no longer available.”
• Effect of Different Doses of Tomato Lycopene on Blood Pressure in Pre-hypertensive Otherwise Healthy Subjects
  NCT00637858 · TERMINATED · slow accrual
  “difficulty to enroll more subjects”
• Effects of TNF-alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and Psoriasis
  NCT00477191 · TERMINATED · slow accrual
  “Difficulty in recruitment.”
• DORADO-AC-EX - A Long-Term Safety Extension Study to the Phase 3 DORADOC-AC Study (Protocol DAR-312) of Darusentan in Resistant Hypertension
  NCT00389675 · TERMINATED · futility
  “Study DAR-312 did not meet its primary co-endpoints.”
• Genetic Determinant of Blood Pressure Sensitivity to Salt Intake
  NCT01706887 · TERMINATED · slow accrual
  “end of recruitment period was reach”
• Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study
  NCT01009944 · WITHDRAWN · funding business
  “Not funded.”
• Home Blood Pressure-guided Antihypertensive Intervention for Elderly (HBP-GUIDE) Study
  NCT00334724 · WITHDRAWN · slow accrual
  “Patients were not appropriately enrolled”
• Treatment of Insulin Resistance in Hypertensive, Obese Adolescents
  NCT00185705 · TERMINATED · logistics pi
  “Primary investigator moved to different university”
• DORADO-EX: Long-Term Safety Extension Study to the Phase 3 DORADO Study (Protocol DAR-311) of Darusentan in Resistant Hypertension
  NCT00353574 · TERMINATED · futility
  “Study DAR-312 did not meet primary co-endpoints”
• Valsartan in Cardiovascular Disease With Renal Dysfunction (The V-CARD) Study
  NCT00140790 · TERMINATED · slow accrual
  “The number of actual events was extremely low. We extended the study period, but it was still not enough. Also, many patients were loss of follow up.”
• The Renin-Angiotensin System in Essential Hypertension
  NCT00141583 · TERMINATED · slow accrual
  “Insufficient accrual rate”
• Genetic Mechanisms in Human Hypertension
  NCT01456208 · TERMINATED · funding business
  “Funding stopped”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.