Epilepsy

Why trials studying Epilepsy stopped, in this sample of ClinicalTrials.gov.

26 stopped trials with a clear reason; 96% ended for non-scientific reasons.

Trials

• Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery
  NCT06280092 · TERMINATED · logistics pi
  “PI has passed away”
• Energy Expenditure and Quality of Life in Epilepsy
  NCT04546711 · WITHDRAWN · funding business
  “decided not to process with study”
• IMPACT of AspireSR® for VNS Therapy on Healthcare Resource Utilisation and Clinical Outcomes.
  NCT05975931 · TERMINATED · logistics pi
  “The decision to terminate was taken based on study team capacity not sufficient and alignment with the sponsor.”
• An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE
  NCT04912856 · TERMINATED · funding business
  “Sponsor decision; not a safety decision”
• Manipulating and Optimizing Brain Rhythms for Enhancement of Sleep
  NCT05089682 · TERMINATED · logistics pi
  “Unable to enroll subjects due to COVID and complexity of study.”
• A Study to Test the Blood Concentration of 4 Padsevonil Product Variants and the Effect of Food on Padsevonil
  NCT04283136 · WITHDRAWN · funding business
  “Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizures”
• Olfactive Discriminative Ability of Dogs When Confronted With Seizure and Non-seizure Samples // Identification of Potential Biomarkers for Epilepsy in Human Sweat.
  NCT04266990 · TERMINATED · logistics pi
  “COVID-10 outbreak forced us to cancel the study”
• Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Interictal Dysfunction in Epilepsy
  NCT02950506 · WITHDRAWN · funding business
  “Lack of resources”
• Intraoperative Brain Microdialysis to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection.
  NCT04531722 · WITHDRAWN · funding business
  “No subjects were enrolled and there was not funding to continue the study”
• Myelin Imaging Changes In Patients With Neurosurgical Diseases
  NCT03698838 · TERMINATED · logistics pi
  “Principal Investigator left Institution”
• Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery
  NCT04344626 · WITHDRAWN · funding business
  “We don't have funding to proceed with this study.”
• Evaluation of Krio in Children and Adults With Epilepsy
  NCT03202108 · WITHDRAWN · manufacturing supply
  “Product manufacturing issues.”
• A Pediatric Drug Study to Determine the Long-term Safety and Tolerability in Children and Adolescents (4-17 Years in Age) Taking the Drug
  NCT03108729 · WITHDRAWN · regulatory
  “The study was not withdrawn for safety reasons. The sponsor received approval for the treatment of partial-onset seizures in patients 4 years of age and older”
• fMRI Guided TMS Enhancement of Associative Memory Networks
  NCT02749422 · TERMINATED · slow accrual
  “This study was closed prematurely due to longer-than-expected recruitment times.”
• Repeated TMS at Low Frequencies to Reduce Seizure Occurrence
  NCT03154307 · TERMINATED · slow accrual
  “Low Recruitment”
• HOPE-Epilepsy Trial
  NCT01744275 · SUSPENDED · funding business
  “Lack of funding”
• Analysis of Lateralization of Language in Epileptic Children by Near-infrared Spectroscopy (NIRS)
  NCT02799108 · TERMINATED · slow accrual
  “inclusion difficulty”
• Cognitive Effects of Vinpocetine in Healthy Adults and Patients With Epilepsy
  NCT02011971 · SUSPENDED · regulatory
  “We are now considering revision of the IND to determine maximum tolerated dose”
• Brain Dynamics in Different Stages of Arousal and Anesthesia
  NCT01574443 · TERMINATED · logistics pi
  “Feasibility issues for subject recruitment and PI left the institution”
• Pharmacodynamics of Nasal and Buccal Midazolam Using EEG
  NCT01316445 · TERMINATED · funding business
  “Funding agency no longer provide support.”
• Efficacy and Safety of the Use of Memantine for Preserving Cognition in Adult Patients With Epilepsy
  NCT00986115 · WITHDRAWN · slow accrual
  “our site was unable to enroll any qualified subjects”
• Cerebral Metabolic Changes Associated With Thalamic Stimulation
  NCT01141764 · TERMINATED · slow accrual
  “Very slow and infrequent recruitment, availability of the imaging procedure at Adult Centre”
• P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.
  NCT00524134 · TERMINATED · logistics pi
  “PI left the institution.”
• A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures
  NCT00699283 · TERMINATED · futility
  “An interim analysis revealed the study was unlikely to attain a positive outcome for the efficacy analysis. No safety concerns were detected”
• Affective Processing in Depression and Epilepsy
  NCT00855725 · TERMINATED · logistics pi
  “PI wanted to discontinue study.”
• Clinical Trial : TROCC (Quick Oral Treatment of Cluster Epileptic Seizures)
  NCT00376766 · TERMINATED · slow accrual
  “recruitment recruitment recruitment recruitment difficulties”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.