Depression

Why trials studying Depression stopped, in this sample of ClinicalTrials.gov.

66 stopped trials with a clear reason; 91% ended for non-scientific reasons.

Reason	Trials	Share
slow accrual	22	33%
logistics pi	17	26%
funding business	17	26%
regulatory	3	5%
other	3	5%
safety	2	3%
manufacturing supply	1	2%
futility	1	2%

Trials

Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIV
NCT07007221 · WITHDRAWN · funding business
“Study was not initiated because funding was not received.”
Intervention for Rural Cancer Patients
NCT05091593 · WITHDRAWN · funding business
“No funding”
The Sequestration of Holistic Stress Management Techniques for Adults
NCT06098755 · WITHDRAWN · slow accrual
“No Participants Enrolled”
Efficacy of Probiotics for Parkinson Disease (PD)
NCT06118294 · WITHDRAWN · logistics pi
“PI has retired”
Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDD
NCT06011577 · TERMINATED · safety
“Study REL-1017-304 was terminated early by the Sponsor following the prespecified interim analysis for sample size re-estimation conducted in study REL-1017-302. Safety assessments were performed in both studies in accordance with the study protocols”
Venlafaxine for the Prevention of Depression in Patients With Head and Neck Cancer
NCT05724849 · WITHDRAWN · funding business
“Issues with funding”
Equine Assisted Services in Children and Adolescents With Mental Illness
NCT05670990 · WITHDRAWN · slow accrual
“due to methodological problems with the recruitment.”
Digital Therapeutic for Adolescent Depressive Symptoms in Hematology, Oncology, and Weight Management
NCT05351866 · TERMINATED · slow accrual
“Low Enrollment”
PREGBRAIN - Magnetic Stimulation of the Brain in Depressed Pregnant Women
NCT04867889 · WITHDRAWN · slow accrual
“Difficult to recruit participants”
Digital Therapeutic for Adolescent Depressive Symptoms in Cardiology and Gastroenterology
NCT05461599 · TERMINATED · slow accrual
“Enrollment too low”
The Effects of Animal Assisted Therapy in Outpatient Psychiatry Clinics
NCT05326074 · TERMINATED · regulatory
“IRB Concerns”
C-STRESS: A Mental Health App for College Students With Depression
NCT05776901 · TERMINATED · funding business
“Grant termination without continuation.”
The CONNECT Program: Testing a Telephone-Based Mental Health Intervention for Older Adults
NCT05120765 · WITHDRAWN · other
“Change in study design was implemented and the study design no longer follows a pilot randomized controlled trial.”
A Coach-Guided Online Acceptance and Commitment Therapy (ACT) Intervention for Stroke Survivors
NCT05097040 · WITHDRAWN · logistics pi
“The research team decided not to implement this study.”
Antidepressant Effects of TS-161 in Treatment-Resistant Depression
NCT04821271 · TERMINATED · slow accrual
“due to low recruitment”
ANGIOTENSIN AGENTS AND REDUCTION OF THE PRESCRIPTION OF ANTIDEPRESSANT DRUGS: A RETROSPECTIVE COHORT STUDY USING REAL-WORLD DATA
NCT04899206 · WITHDRAWN · funding business
“Lack of funding”
Writing to Alleviate Violence Exposure for Transgender Women (WAVE-TW)
NCT04305977 · WITHDRAWN · logistics pi
“There was enrollment in the qualitative phase that proceeded this planned open pilot trial. However, community partner experienced barriers to recruitment and enrollment in the context of COVID and needed prioritize non-research functions.”
Treatment of Depressive Symptoms in Older Individuals in Isolation During Covid-19
NCT04508868 · TERMINATED · regulatory
“Study terminated due to changes in government restrictions. Collected data to be presented as a pilot study.”
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Depression
NCT04211467 · WITHDRAWN · funding business
“Company shifted focus”
Tofacitinib in Depression (TIDE)
NCT04141904 · TERMINATED · logistics pi
“Covid-19 pandemic”
HEAlth Dialogues for Patients With Mental Illness in Primary Care
NCT05181254 · TERMINATED · funding business
“Lack of funding.”
Building Regulation in Dual Generations
NCT04347707 · TERMINATED · logistics pi
“The trial was ended after one year due to the suspension of in-person research as a result of the COVID-19 pandemic. We have returned to the program development stage as we explore telehealth alternative options.”
Single-Session Computerized Mental Health Intervention for Rural Indian Adolescents
NCT04020549 · WITHDRAWN · other
“In collaboration with community partners, we determined that the reading level required for the intervention did not make it suitable for the adolescents.”
A Feasibility Study of a Transdiagnostic Compassion Focused Therapy (CFT) Group for Older Adults
NCT04039542 · TERMINATED · logistics pi
“COVID-19 restrictions limited recruitment”
Global CALM Implementation Study
NCT04499690 · TERMINATED · logistics pi
“Study recruitment \& data collection ceased in Dec 2022 in part due to funding shortages and the impact of the COVID-19 Pandemic. 40 clinician-participants consented; 35 completed measures; no data were analyzed or published; REB was closed Nov 2024.”
Evaluating a Group-based Therapeutic Yoga Program for Burnout
NCT03973216 · WITHDRAWN · logistics pi
“COVID-19 caused the group format to shift, therefore the intervention was not delivered in the same manner as the one described in the proposal. The study was stopped as the intervention may not be delivered as planned even following COVID-19.”
Creatine Monohydrate Use for Preventing Altitude Induced Depression
NCT03433651 · WITHDRAWN · funding business
“Unable to locate grant funding.”
LUPUS Brain: tACS to Target the Neurophysiology of Depression, Cognitive Deficits, and Pain in Patients With SLE
NCT04141046 · TERMINATED · funding business
“Terminated due to end of funding period.”
Internet-delivered Interventions for Stress, Anxiety and Depression in the Workplace
NCT03271645 · WITHDRAWN · logistics pi
“logistics”
Mobile Virtual Positive Experiences for Anhedonia
NCT03715400 · SUSPENDED · logistics pi
“COVID-19 Restrictions for in-person study procedures”
Leucine for Depression Study (L-DEP)
NCT03557684 · TERMINATED · logistics pi
“COVID-19”
Group Metacognitive Therapy for Anxiety and Depression in Cancer Survivors
NCT03424512 · TERMINATED · logistics pi
“Covid-19 halted study, reorganisation of the clincial service and staff leaving posts made recruitement to a group unfeasible”
Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD)
NCT03387033 · TERMINATED · funding business
“enrollment closed due to lack of funding”
Effect of TF-TAVR on Emotional Status, Quality of Life, Frailty and Inflammation
NCT03308435 · TERMINATED · futility
“futility”
Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine
NCT02969876 · TERMINATED · slow accrual
“Site was unable to reach Sponsor recruitment goals.”
Transdiagnostic Treatment of Emotional Disorders for Women in a Homeless Situation
NCT04392856 · TERMINATED · logistics pi
“COVID-19 Pandemic”
The Influence of TaKeTiNa Music Therapy, Traditional Chinese Acupuncture and Clown Theatrical Performance on Quality of Life and the Therapeutic Process of Patients Undergoing Allogenic Stem Cell Transplantation
NCT02976558 · TERMINATED · logistics pi
“Due to organisational issues, the study had to be completed prematurely.”
Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)
NCT02813447 · TERMINATED · logistics pi
“COVID-19 hold”
Brain Function in Depression and Insulin Resistance
NCT02889211 · TERMINATED · logistics pi
“Principal Investigator Left University”
Physiological and Cognitive Biomarkers for Ketamine's Antidepressant Effects
NCT02669043 · TERMINATED · funding business
“Funding ended.”
Biomarkers in Depressed Inpatients Receiving Accelerated rTMS
NCT03628573 · WITHDRAWN · slow accrual
“Lack of recruitment”
Intranasal Ketamine for Late-Life Depression and Suicidal Ideation
NCT02295787 · WITHDRAWN · funding business
“No funding”
Mental Health and Resilience in Emerging Adulthood
NCT01994122 · TERMINATED · slow accrual
“The study has been terminated because of recruitment difficulties and lack of further funding”
Neuroimaging Predictors of Antidepressant Treatment Outcome
NCT02000726 · WITHDRAWN · funding business
“Lack of funding to complete the trial phase of the study.”
Self-help Program Via Internet for Adolescents With Cancer
NCT01510236 · WITHDRAWN · slow accrual
“a feasibility study showed low recruitment and adherence”
Investigate Efficacy & Safety of RO4995819 vs. Placebo as Adjunct Tx in Patients w/Major Depressive Disorder
NCT01733654 · WITHDRAWN · slow accrual
“no participants enrolled”
Oral Ketamine in the Treatment of Depression and Anxiety in Patients With Cancer
NCT01680172 · TERMINATED · slow accrual
“Slow enrollment”
Short-term Cognitive Training in Late-life Depression
NCT01748032 · TERMINATED · slow accrual
“Low Recruitment”
A Pilot Trial of Interpersonal Psychotherapy for the Treatment of Depression in Patients With Prostate, Colorectal, Lung and Pancreatic Cancer
NCT01940237 · TERMINATED · slow accrual
“Low recruitment”
Open-Label Creatine Study for Female Meth Users
NCT02189915 · TERMINATED · funding business
“Received funding for the next phase of the study”
The Effect of Melatonin on Depression, Anxiety, Cognitive Function and Sleep Disturbances in Breast Cancer Patients
NCT01355523 · TERMINATED · slow accrual
“Inclusion rate not as expected. Not financially possible to involve other centres.”
Evaluation of the Bounce Back Program
NCT01324648 · TERMINATED · slow accrual
“Couldn't enrol sufficient participants”
Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients
NCT01246310 · TERMINATED · slow accrual
“The number of patients enrolled was insufficient to match the calculated sample size and to carry out statistical analyses”
Safety and Efficacy of EVT 101 in Treatment-Resistant Depression
NCT01128452 · TERMINATED · regulatory
“Evotec has indicated that this study was discontinued due to a clinical hold issued by the FDA”
Investigation of Neuro-hormonal Mechanisms of Hunger, Fullness and Obesity.
NCT01008371 · WITHDRAWN · slow accrual
“No recruitment”
Primary Care iSBIRT to Reduce Serious Teen Health Risks
NCT00891631 · WITHDRAWN · funding business
“Grant application was not funded”
A Study Of Kappa Opioid Receptor Occupancy Of PF-04455242, Using PET (Positron Emission Tomography)
NCT00939887 · TERMINATED · safety
“This study was terminated on January 6, 2010, due to toxicology findings in animals exposed to PF-04455242 for three months.”
Depression and Cardiovascular Risk Markers: Effects of Rosuvastatin Therapy
NCT00951132 · WITHDRAWN · slow accrual
“Failure to include patients”
Sinusitis and Facial Pain Disorders Anti-Depression Trial
NCT00754793 · TERMINATED · slow accrual
“poor recruitment”
Affective Processing in Depression and Epilepsy
NCT00855725 · TERMINATED · logistics pi
“PI wanted to discontinue study.”
Study to Evaluate the Effectiveness of Certain Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressants During Pregnancy and Evaluate Newborn Outcomes
NCT00553917 · TERMINATED · slow accrual
“Poor recruitment to experimental arms and study remained unfunded”
Switching to Duloxetine to Ameliorate SSRI-Induced Sexual Dysfunction
NCT00398632 · TERMINATED · slow accrual
“Unable to recruit subjects”
Assessment of the Safety and Effectiveness of Cortical Stimulation in Subjects With Major Depressive Disorder
NCT00380042 · TERMINATED · funding business
“Study terminated as a result of the dissolution of the Sponsor.”
Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral Contraceptives
NCT00089414 · TERMINATED · manufacturing supply
“Informed by manufacturer that CDB-2914 crosses blood-brain barrier invalidating Arm #3 of protocol.”
Sedation and Psychopharmacology in Critical Care
NCT00205517 · TERMINATED · other
“End point reached at interim analysis”
Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors
NCT00031798 · TERMINATED · funding business
“low accrual; loss of funding”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.