Critical Illness

Why trials studying Critical Illness stopped, in this sample of ClinicalTrials.gov.

18 stopped trials with a clear reason; 94% ended for non-scientific reasons.

Trials

• Impact of Interactive ICU Diary on Psychological Distress
  NCT06512987 · TERMINATED · logistics pi
  “The study was terminated due to insufficient staffing, which impacted the ability to continue subject enrollment and study operations.”
• Post Intensive Care Unit Atrial Fibrillation
  NCT05860894 · TERMINATED · slow accrual
  “Insufficient recruitment”
• Assessment of Kidney Function and Osteomuscular Status After Critical Care
  NCT04980092 · SUSPENDED · slow accrual
  “Enrollment difficulties”
• Gastric US in ICU Patient
  NCT05526105 · WITHDRAWN · logistics pi
  “Not enough resources (time and manpower) to run study.”
• Physiological Effects of 38°C vs. 22°C Fluid Therapy in Critically Ill Patients
  NCT04576806 · WITHDRAWN · logistics pi
  “Other research priorities during Covid-19 pandemic.”
• Detection of Neuromuscular Complications in Critically Ill Patients
  NCT04541602 · TERMINATED · logistics pi
  “PI and the majority of the study team left institution.”
• Collective Accuryn Physiologic Signals and Signatures
  NCT03817281 · WITHDRAWN · slow accrual
  “Lack of Enrollment”
• Body Positioning and Pulmonary Aeration During Mechanical Ventilation
  NCT04176445 · TERMINATED · logistics pi
  “The trial was stopped prematurely due to the COVID-19 pandemic”
• Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients with Sepsis
  NCT04203524 · TERMINATED · futility
  “No significant differences between 2 study arms”
• Peripheral Oxygen Saturation (SpO2) Directed Oxygen Therapy
  NCT02999932 · TERMINATED · slow accrual
  “Slow inclusion”
• Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis
  NCT03012360 · TERMINATED · slow accrual
  “lack of inclusion pandemic, investigator reluctance, lower than expected incidence of infection”
• Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
  NCT02903407 · TERMINATED · slow accrual
  “All enrolled participants completed the study protocol but the study was terminated prior to the goal number of participants due to low recruitment”
• The Effect of Naloxegol on Refractory Constipation in the Intensive Care Unit
  NCT02705378 · WITHDRAWN · logistics pi
  “PI left institution. Protocol never submitted to the IRB, no contract executed only Confidentiality Agreement, and study not done.”
• Treatment of Muscle Weakness in Critically Ill Patients
  NCT02247895 · TERMINATED · slow accrual
  “difficulty meeting enrollment goals”
• Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)
  NCT02742974 · TERMINATED · logistics pi
  “Lack of research personnel”
• Single Dose Enteral Tranexamic Acid in Critically Ill Patients
  NCT01683747 · TERMINATED · slow accrual
  “Lower than anticipated enrollment”
• Anabolic Steroids for Nutritional Rehabilitation of Critically Ill Patients
  NCT00242463 · TERMINATED · manufacturing supply
  “drug no longer available in canada”
• Near Infrared Spectroscopy (NIRS) in Severe Sepsis
  NCT00167596 · TERMINATED · funding business
  “recruitment was stopped as consequence of cessation of funding (economic crisis)”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.