Asthma

Why trials studying Asthma stopped, in this sample of ClinicalTrials.gov.

36 stopped trials with a clear reason; 83% ended for non-scientific reasons.

Trials

• Coping With Asthma Throughout Life Management Program
  NCT07044388 · WITHDRAWN · logistics pi
  “PI departure from institution”
• Wearable Auscultation Device Validation in Children
  NCT06112080 · TERMINATED · logistics pi
  “The Principal Investigator is departing from the study site.”
• A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma.
  NCT05763121 · TERMINATED · funding business
  “Program stopped due to the benefit risk profile no longer supports further development in the intended patient population.”
• Step-up to Medium Strength Triple Therapy vs High Strength ICS/LABA in Adult Asthmatics Uncontrolled on Medium Strength ICS/LABA
  NCT05018598 · TERMINATED · slow accrual
  “The study was prematurely stopped due to extensive challenges in patient recruitment. The Sponsor issued a notification of early study termination to all investigational sites and all external stakeholders.”
• A Study to Evaluate the Efficacy and Safety of AK120 in the Treatment of Subjects With Moderate-to-severe Asthma
  NCT05155020 · TERMINATED · funding business
  “The clinical development strategy has been changed”
• Prostaglandin E2 as a Critical Mediator of Sex Disparities in Asthma
  NCT03825302 · WITHDRAWN · funding business
  “No funding available.”
• Safety and Efficacy Active Drug vs. Placebo in Subjects With Asthma
  NCT04987944 · TERMINATED · funding business
  “Strategic decision to discontinue the study based on adjusted clinical development plan. This decision is not based on any safety concerns.”
• A Trial of SHR-1703 in Healthy Subjects
  NCT04855591 · TERMINATED · funding business
  “Adjustment of the clinical development plan for this product globally”
• A Study to Test if TEV-53275 is Effective in Relieving Asthma
  NCT04847674 · TERMINATED · funding business
  “Stopped for strategic reasons”
• Factors Issued From Functional Exploration Associated to SAHOS in Asthmatic Children
  NCT04624815 · TERMINATED · logistics pi
  “logistics problems”
• Ciliation and Mucus Rheology Parameters Determined Via Air-liquid-interface Cell Cultures in Non-smoking, Smoking, COPD and Asthmatic Patients
  NCT03187860 · TERMINATED · slow accrual
  “Inclusions was stopped at 30 patients. Investigators did not wish to extend inclusions.”
• Integrated Digitally Enhanced Care for Long-term Conditions- Asthma
  NCT03511482 · WITHDRAWN · funding business
  “Lack of Funding”
• A Safety and Efficacy Study of Intranasal GSK2245035 in Adults With Allergic Asthma
  NCT03707678 · WITHDRAWN · funding business
  “After careful review of new data on GSK2245035, GlaxoSmithKline has decided to cancel this study.”
• Lung Clearance Index (LCI) in Pediatric Patients With Obstructive Lung Disease
  NCT02950116 · TERMINATED · logistics pi
  “Availabe time for inclusion ended (master thesis)”
• Randomized, Placebo-controlled Study Comparing Efficacy of Fluticasone/Salmeterol Combination to Advair in Asthmatics
  NCT02496715 · WITHDRAWN · funding business
  “Development terminated.”
• Small Airway Function of Fluticasone/Formoterol (Flutiform®) and Fluticasone/Salmeterol
  NCT02491970 · TERMINATED · slow accrual
  “Difficulty of patients enrollments”
• Assessment of a Mobile Intervention to Increase Adherence to Asthma Medication Among Adolescents
  NCT02426814 · WITHDRAWN · funding business
  “Lack of funding”
• Web System for Engaging Families & Doctors in Continuous Asthma Quality Improvement
  NCT02435394 · WITHDRAWN · regulatory
  “After IRB review, this study is no longer considered a clinical trial”
• Longitudinal Observational Study in Prematurely Born Preschool Children: Assessment of Lung Function Parameters
  NCT02636933 · TERMINATED · logistics pi
  “Covid-2019”
• Study to Examine the Cytokine Levels, Gene Expression and Safety of a Single Nasal Dose of JNJ-43260295, in Healthy Participants, and Atopic Participants With Mild to Mild-Persistent Asthma
  NCT02243189 · TERMINATED · manufacturing supply
  “Under enrollment and IP supply expiring.”
• A Study of Lebrikizumab in Adolescent Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
  NCT01875003 · TERMINATED · funding business
  “Sponsor decision to discontinue lebrikizumab development for the treatment of asthma.”
• Study of Efficacy and Safety of Brodalumab Compared With Placebo in Adults With Inadequately Controlled Asthma With High Bronchodilator Reversibility
  NCT01902290 · TERMINATED · futility
  “Study terminated early due to lack of efficacy observed following interim analysis in Q2 2015. Study Closed once all sites were closed in eClinical”
• Mechanisms of Response to Diesel Exhaust in Subjects With Asthma
  NCT01799746 · WITHDRAWN · slow accrual
  “The Airways Biology Initiative closed in December, 2015. This study was closed with the Penn IRB at that time. No subjects were recruited for this trial.”
• Exercise Training in Asthma
  NCT00820716 · TERMINATED · slow accrual
  “Difficulties in recruiting patient”
• CryoSpray Ablation(tm)Thoracic Patient Registry
  NCT00785239 · WITHDRAWN · funding business
  “Business Reasons”
• Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease
  NCT00642616 · TERMINATED · safety
  “Terminated upon recommendation of the Data Safety Monitoring Board (DSMB)”
• Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics (Glitz Asthma)
  NCT00787644 · TERMINATED · safety
  “new safety concerns which emerged about pioglitazone during the trial”
• Sensitivity and Specificity of Aridol Challenge for a Diagnosis of Asthma by a Specialist Pulmonologist
  NCT00491153 · TERMINATED · slow accrual
  “due to low recruitment rate secondary to very stringent inclusion criteria”
• Management of Asthma Patients Guided by Exhaled Nitric Oxide (eNO)
  NCT00739219 · TERMINATED · slow accrual
  “Study terminated due to lack of care guidelines in the protocol.”
• Elucidation of Acid-Induced Pulmonary Inflammation
  NCT00361972 · TERMINATED · slow accrual
  “limited recruitment”
• Childhood Asthma Research and Education (CARE) Network Trial - Montelukast or Azithromycin for Reduction of Inhaled Corticosteroids in Childhood Asthma (MARS)
  NCT00471809 · TERMINATED · futility
  “The CARE Network DSMB recommended to the NHLBI that the MARS trial be terminated, based on a futility analysis with 55 randomized children.”
• Magnetic Resonance (MR) in Asthmatic Patients
  NCT00188487 · TERMINATED · funding business
  “no funding”
• Comparing Asthma Action Plans for Pediatric Asthma
  NCT00136305 · TERMINATED · logistics pi
  “PI moved to a different institution”
• Prevention of Asthma With Levocetirizine (36 Month Treatment) in Young Children Suffering From Eczema (Atopic Dermatitis) and Sensitized to Grass Pollen and House Dust Mite and Having Completed the Previous EPAAC Trial (NCT00152464)
  NCT00160563 · TERMINATED · futility
  “The predecessor study A00309 (NCT00152464) did not show statistical significance in time to onset of asthma between the levocetirizine and placebo groups.”
• Montelukast Added to Standard Therapy for Acute Asthma in Children Age 6-14 Years
  NCT00353184 · TERMINATED · futility
  “Results of the interim analysis suggested no significant diff between study groups.”
• Inhaled Fluticasone Propionate: Effect on Parameters of Bone Metabolism in Patients With Mild to Moderate Asthma
  NCT00409630 · WITHDRAWN · funding business
  “Sponsor decided against going forward with the study.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.